@albertcardona@mathstodon.xyz
@albertcardona@mathstodon.xyz avatar

albertcardona

@albertcardona@mathstodon.xyz

How does the brain work? Someday, we'll figure it out.
Group Leader, MRC LMB, and Professor, University of Cambridge, UK.
#neuroscience #Drosophila #TrakEM2 #FijiSc #CATMAID #connectomics #connectome #vEM #iNaturalist #entomology
Born at 335 ppm.
Brains, signal processing, software and entomology: there will be bugs.

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albertcardona, to Trains
@albertcardona@mathstodon.xyz avatar

In Europe, flying is cheaper than taking the train.

It's an embarrassment, and a major problem: we have to stop flying for silly short distances. Realise that the overheads of flying (reaching the airport, awaiting 2 hours, the flight, the unloading, reaching the destination) largely cancel out any time gains of flying. And the carbon costs are utterly untenable. Not to speak of the modern, dire conditions of the whole flying "experience".

Another embarrassment is that train connections can't be guaranteed when across countries or companies. They aren't even coordinated. As if those who commission and set the schedules didn't travel by train themselves, at least not internationally. In considering how tiny most European countries are, it's frankly bizarre.

There are so many destinations one could travel by train to, yet in practice, it's not sensible. A disgrace.

The upside is that it can be fixed.

albertcardona, to science
@albertcardona@mathstodon.xyz avatar

Not sure what those who advocate for the use of ChatGPT in scientific writing have in mind. It is the very act of writing that helps us think about the connections and implications of our results, identify gaps, and devise further experiments and controls.

Any science project that can be written up by a bot from tables of results and associated literature isn’t the kind of science that I’d want to do to begin with.

Can’t imagine completing a manuscript not knowing what comes next, because the writing was done automatically instead of me putting extensive thought into it.

And why would anyone bother to read it if the authors couldn’t be bothered to write it. Might as well put up the tables and figures into an archive online, stamp a DOI on it, and move on.

albertcardona, (edited ) to science
@albertcardona@mathstodon.xyz avatar

If you are drafting figures for a scientific paper or presentation, remember that https://scidraw.io/ exists: a repository of free SVG cartoons for science.

is supported by the Sainsbury Wellcome Centre – @SWC_Neuro

All content on SciDraw is shared under creative commons license (CC-BY) unless stated otherwise.

albertcardona, to random
@albertcardona@mathstodon.xyz avatar

Leslie Lamport, of LaTeX fame, is a very accomplished mathematician and computer scientist with a Turing award for his work on “fundamental contributions to the theory and
practice of distributed and concurrent systems”. He just published a draft of his new book:

"A science of concurrent programs"

https://lamport.azurewebsites.net/tla/science.pdf

True to his pedagogic approach to everything he does, "The book assumes only that you know the math one learns before entering a university." Even the appendices are fantastic. Can only wish I'll remain this lucid at his 82 years old.

futurebird, to random
@futurebird@sauropods.win avatar

The more I learn about light pollution harms insects, the more I want to try to help... do something about it.

But I live in NYC. It feels like an impossible ask. A whole city devoted to making the most light pollution possible.

I strongly suspect that we'd see a greater variety of wildlife if we could dim the light a little.

Just using colors like red light can help. So can dark hours and motion sensors.

What if one day, as a treat, every New Yorker got to see the milky way?

albertcardona,
@albertcardona@mathstodon.xyz avatar

@futurebird

When every Angeleno got to see the Milky Way, some called the police to report strange lights in the sky:

https://www.nytimes.com/2008/08/31/business/31essay.html

That, more than anything, emphasizes the need for black skies. We can't live with out backs to nature.

The article (disable javascript and reload to read it in full) also discusses the benefits of dark skies and the costs of not doing so (2008): "The Dark-Sky group estimates that badly designed outdoor lighting wastes $10 billion in energy a year."

pvonhellermannn, to random
@pvonhellermannn@mastodon.green avatar

Half thinking of starting an hashtag here, about the dire, dire state of UK (global?) higher education. Sharing nuggets of senior management decisions, neoliberal language, and overall slow collapse.

Won’t work of course because most of us can’t risk honesty, but honestly: the everyday reality of what is happening deserves recording in all its depressing and damning detail.

albertcardona,
@albertcardona@mathstodon.xyz avatar

@pvonhellermannn

Accountability isn’t ever for them. It’s that old approach to crises from “Yes, Prime Minister”:

Bernard Woolley : What if the Prime Minister insists we help them?
Sir Humphrey Appleby : Then we follow the four-stage strategy.
Bernard Woolley : What's that?
Sir Richard Wharton : Standard Foreign Office response in a time of crisis.
Sir Richard Wharton : In stage one we say nothing is going to happen.
Sir Humphrey Appleby : Stage two, we say something may be about to happen, but we should do nothing about it.
Sir Richard Wharton : In stage three, we say that maybe we should do something about it, but there's nothing we can do.
Sir Humphrey Appleby : Stage four, we say maybe there was something we could have done, but it's too late now.

https://m.imdb.com/title/tt0751831/characters/nm0001329

albertcardona, to Neuroscience
@albertcardona@mathstodon.xyz avatar

Loren Looger, legendary protein wrangler, who always generously shared their genetically encoded calcium indicators and more while still in development and unpublished, is asking for labs to co-write grants with him:

"Dear science world, I need help, please. If you like the tools and data we generate, and our shareware attitude, can you please co-apply for funding with us? It turns out that I'm terrible at writing grants, and we need $$ or else we can't make more GCaMPs, RCaMPs, SnFRs (we've branched out to neuromodulators and neuropeptides), FPs, viruses, tags, etc. We'll also make whatever you want, but we need $$ to do it. DM or email me, sooner is better. Sorry to be desperate, but we want to keep doing this, and I'm not sure we can."

https://profiles.ucsd.edu/loren.looger

elduvelle, (edited ) to academia
@elduvelle@neuromatch.social avatar

People who write #ResearchGrants: do you write about

  1. projects that you’ve already almost completed (hiding the fact that they’re almost completed, so that you can use the funding for completely new projects), or
  2. new projects that you haven’t really started yet (for which you might just have some preliminary data)?

Do you think 1) is unethical? Do you think 1) is necessary? Do you think 1) has the highest chances of funding? Please comment :)

#Academia #GrantWriting #Research

albertcardona, (edited )
@albertcardona@mathstodon.xyz avatar

@janbogar @RichardShaw @maartjeoostdijk @elduvelle

PeerJ, PLoS, eLife, EMBO Journal. We are trying.

Now the onus is on removing from evaluation criteria the "it's a <glamour journal> paper" shortcut, and disqualify anyone using that from membership in search committes or grant/dept./unit evaluation panels.

And to further drive the stake in by raising the issue with high-retraction rate journals, among which many glamour journals. Publishing in a glamour journal should sound suspicious, should require special dispensation to be included among evaluation criteria for recruitment/promotion/awards.

albertcardona, to ChatGPT
@albertcardona@mathstodon.xyz avatar

Donal Knuth poses questions to . One of his comments: “It's amazing how the confident tone lends credibility to all of that
made-up nonsense.” https://cs.stanford.edu/~knuth/chatGPT20.txt

exhibits great eloquence yet fails fact checking spectacularly.

albertcardona, to random
@albertcardona@mathstodon.xyz avatar

Rewilding the internet:

"Just like the crime-ridden, Corbusier-like towers Moses crammed people into when he demolished mixed-use neighborhoods and built highways through them, today’s top-down, concentrated internet is, for many, an unpleasant and harmful place. Its owners are hard to remove, and their interests do not align with ours."

"Apple and Google’s email clients manage nearly 90% of global email. Google and Cloudflare serve around 50% of global domain name system requests."

"For many people across the generations today, platforms like Facebook or TikTok are the internet. They’ve long dwelled in walled gardens they think are the world."

https://www.noemamag.com/we-need-to-rewild-the-internet/

By Maria Farrell and Robin Berjon.
@mariafarrell @robin

albertcardona, to random
@albertcardona@mathstodon.xyz avatar

Michal Olšiak, Czech sculptor, did it again. This time, giant sculptures of insects. Fascinating exhibition, wish I could go there.

Ants, flies, weevils, beetles, and more. The gallery:

https://www.idnes.cz/kultura/vytvarne-umeni/michal-olsiak-megabrouci-vystava-brouci-hmyz-modely.A240103_204921_vytvarne-umeni_kurl/foto/COC5ced1bb436_174616_3915720.jpg

(If a Czech native speaker could translate his wikipedia page to English or French or Spanish, that would be greatly appreciated: https://cs.wikipedia.org/wiki/Michal_Ol%C5%A1iak )

Big statue of a mosquito with a red abdomen, engorged with blood.
Human-sized ant statues shown tending to aphids.

albertcardona, to random
@albertcardona@mathstodon.xyz avatar

on the news:

https://www.theglobeandmail.com/canada/article-amateur-entomologists-insects-quebec/

And a letter to the editor emphasises:

"Such tools can impart a sense of wonder at the beauty, complexity and ubiquity of life, revealing unseen worlds in our midst. I have used iNaturalist to document more than 80 species of insects, including many important pollinators, in my modest fifth-floor container garden."

"Even as we depend on such insects for our survival, we also share our urban spaces with them, life finding a way in the most inhospitable places. It is a reminder that our built environment is also theirs, and that we are forever caught in their web of life."–Ryan Whyte

https://forum.inaturalist.org/t/great-article-and-my-letter-to-the-editor-promoting-inaturalist/44007

albertcardona, to random
@albertcardona@mathstodon.xyz avatar

"Ocasio-Cortez attended Boston University, where she double-majored in international relations and economics, graduating cum laude." https://en.wikipedia.org/wiki/Alexandria_Ocasio-Cortez

And on an article denouncing the widespread misogyny that keeps women from being president of the United States, the interviewer refers to AOC as "a former restaurant server and bartender"🤦‍♂️

https://www.theguardian.com/us-news/2023/sep/03/aoc-interview-2024-election-climate-democrat

albertcardona, to random
@albertcardona@mathstodon.xyz avatar

An inverse vaccine to combat autoimmune diseases. How did I miss this giant piece of news!

"Synthetically glycosylated antigens for the antigen-specific suppression of established immune responses", Tremain et al. 2023 https://www.nature.com/articles/s41551-023-01086-2

Surely there are already clinical trials.

Sure beats the crude cyclophosphamide approach to killing antibody-producing B cells that are undergoing mitosis – a protocol I applied back in my PhD times to select for monoclonal antibodies against specific tissues.

albertcardona, to random
@albertcardona@mathstodon.xyz avatar
davidho, to random
@davidho@mastodon.world avatar

Is there a law that describes how the rapid growth in renewable energy is outpaced by the growth in the dumb ways we think of to use that energy?

albertcardona,
@albertcardona@mathstodon.xyz avatar

@davidho

Jevons paradox https://en.m.wikipedia.org/wiki/Jevons_paradox

"... occurs when technological progress or government policy increases the efficiency with which a resource is used (reducing the amount necessary for any one use), but the falling cost of use induces increases in demand enough that resource use is increased, rather than reduced."

albertcardona, (edited ) to Neuroscience
@albertcardona@mathstodon.xyz avatar

The honeybee brain hosts over 600,000 neurons, at a density higher than that of mammalian brains:

"Our estimate of total brain cell number for the European honeybee (Apis mellifera;
≈ 6.13 × 10^5, s = 1.28 × 10^5; ...) was lower than the existing estimate from brain sections ≈ 8.5 × 10^5"

"the highest neuron densities have been found in the smallest respective species examined (smoky shrews in mammals; 2.08 × 10^5 neurons mg^−1 [14] and goldcrests in birds; 4.9 × 10^5 neurons mg^−1 [16]). The Hymenoptera in our sample have on average higher cell densities than vertebrates (5.94 × 10^5 cells mg^−1; n = 30 species)."

Ants, on the other hand ...

"ants stand out from bees and wasps as having particularly small brains by measures of mass and cell number."

From:
"Allometric analysis of brain cell number in Hymenoptera suggests ant brains diverge from general trends", by Godfrey et al. 2021.
https://royalsocietypublishing.org/doi/10.1098/rspb.2021.0199

albertcardona, to random
@albertcardona@mathstodon.xyz avatar

Arcadia is innovating in publishing: witness this manuscript by @PracheeAC et al. 2023

"Phenotypic differences between interfertile Chlamydomonas species" https://research.arcadiascience.com/pub/result-chlamydomonas-phenotypes/release/6

Includes a methods-first approach, aiming at easing how the data was acquired and to make it reproducible. With figures that contain animations without being videos, feeling very natural to the medium (a webpage).

And importantly: no "authors", but "contributors", listed AT THE BOTTOM, in a table sorted in alphabetical order by surname, alongside the role of each contributor. Laudable, and clear. No more first-author last-author nonsense.

And love starting with a section titled "Purpose" and ending with another titled "Next steps". Explicitly embedding the work into the broader stream of science.

futurebird, to random
@futurebird@sauropods.win avatar

Last night our cable internet box randomly died. It’s totally fried and must be replaced. This happened just as my husband got home from work, waking me up to tell me the governor of NY had issued a warning about power outages during the Coronal Mass Ejection (there was a big solar storm last night) — basically I thought the world was ending and put my laptop in the oven. (it’s a faraday cage)

I may have overreacted.

albertcardona,
@albertcardona@mathstodon.xyz avatar

@futurebird

Wasn't this exactly what happened in Los Angeles a long while back:

"So foreign are the real night skies to Los Angeles that in 1994, after the Northridge earthquake jostled Angelenos awake at 4:31 a.m., the observatory received many calls asking about "the strange sky they had seen after the earthquake.""

https://web.archive.org/web/20130729062408/http://articles.latimes.com/2011/jan/04/local/la-me-light-pollution-20110104/2

albertcardona, to uk
@albertcardona@mathstodon.xyz avatar

The amount of kids, all boys, in emergency room for head concussions from playing sports – it's scary. Mostly rugby. Why isn't this sport banned in schools yet? The long-term brain damage is well documented.

KorinnaAllhoff, to random German
@KorinnaAllhoff@ecoevo.social avatar

🚨 New #preprint is online! 🚨

"Many weak and few strong links" seems to be a common pattern in many #EcologicalNetworks. We show that this skewness in interaction strengths can enable stabilising effects of network structure. It should hence receive more attention in #TheoreticalEcology and #EcologicalModelling, especially in studies based on random matrices!

(Btw, just in case you are looking for guest speakers, I highly recommend the first author, Franziska Koch! 😉)

https://doi.org/10.1101/2024.01.25.577181

albertcardona,
@albertcardona@mathstodon.xyz avatar

@KorinnaAllhoff

How interesting. In , the brain – the pattern of synaptic connections among neurons – is also organized with many weak and few strong links.

E.g., Winding et al. 2023, "The connectome of an insect brain":
https://www.science.org/doi/abs/10.1126/science.add9330

albertcardona, (edited ) to climate
@albertcardona@mathstodon.xyz avatar

An act of resistance is to teach your own child to mend clothes, to shop seasonal groceries, to cook a meal, to tend a garden, to ride a bicycle, to observe the procession of the seasons, to dress for the weather.

Instead of buying new clothes, pick up ready to go meals, drive everywhere, keep a constant temperature on the house.

What a strange world we live in. As if we've taken nature for granted. And forgotten our past. And forsaken our future.

futurebird, to random
@futurebird@sauropods.win avatar

Cataglyphis lutea (UAE and parts of India) is a desert dwelling ant, the photos of this ant on iNaturalist caught my eye, since, like Leptomyrmex erythrocephalus (the Spider Ant of Australia), this these little ants fold their gasters over their mesonoma.

Very little is known about Cataglyphis lutea, shockingly little. I can't even find a mention of gaster folding in any of the brief descriptions of this ant.

This is why descriptions are not enough. 1/

(photos by Jonghyn Park and TimL)

A black ant with a red head and black dot eyes clamors over a rock on remarkably long legs. The antennae and legs are very long and evenly spread giving the impression of a spider (hence the common name) The gaster is folded over the mesonoma.

albertcardona,
@albertcardona@mathstodon.xyz avatar

@futurebird

Agree completely, for most animals, their biology and behaviour is largely undescribed.

Here is an ant acting as a pollinator; its limbs and bristles covered in pollen just like those of bees, wasps, butterflies, beetles and flies. For ants, their role in pollination is a well-described ecosystem service and behaviour in the academic literature, and yet, most people don't know about it.

Myrmica rubra, the common red ant, on a dandelion flower
https://www.inaturalist.org/observations/204953480

futurebird, to random
@futurebird@sauropods.win avatar

My mom was the head of a math department at a community college and I have fond childhood memories of the crazy mail she got. I think all math departments get this kind of mail. Basically people who think they've proven the Riemann hypothesis and such. She'd have me look for math errors in them because they always had SO MANY errors.

So, the idea of writing about biology scares me because I don't want to be "one of those guys" for some poor biology department head.

albertcardona,
@albertcardona@mathstodon.xyz avatar

@futurebird

My email folder titled "cranks" is exactly that: a museum of the deluded and their theories on how the brain works. It's frankly extraordinary how fast and loose they go. While I don't reply to them, I keep them like a neuroscientist collects magic tricks the study of which help explain how vision works.

futurebird, to random
@futurebird@sauropods.win avatar

I just saw a sport drink labeled "3x the electrolytes!"

Talk about missing the point. The idea of a drink with some salts and vitamins to replenish you after sweating isn't totally crazy, although most of our diets have too much salt, the idea of a carefully balanced, tasty drink for after a sweaty run ... made a little sense at least.

You'd be paying for them to put in a little salt and potassium but not too much since then...

Clearly I'm overthinking this. More is better drink seawater.

albertcardona,
@albertcardona@mathstodon.xyz avatar

@thecrushedviolet @futurebird

Most insidious I've ever seen was some Nestlé baby food, where the ingredients list didn't list sugar - and the package boasts about "0% sugar added", but the nutritional table shows ~30% sugar. The culprit? They added an enzyme to hydrolize starch, and even marketed it as "easy to digest" – the criminals.

Who would feed a baby food with 30% sugar? For reference, that's like adding 7 teaspoons of sugar to a single-portion yoghurt (125 g).

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