cyrilpedia

cyrilpedia, 10 months ago to random

'Compared to Clarence Thomas’s gifts from the richest 1 percent of Nazi memorabilia enthusiasts, the sudden payment of Brett Kavanaugh’s extravagant credit card debts, or Samuel Alito’s propinquity to hedge fund billionaires, apparently the decision to take out loans to get an education is unforgivable.'

https://www.nybooks.com/online/2023/07/08/the-unforgiven/

cyrilpedia, 10 months ago to random

'Researchers who study how disinformation spreads are under investigation in the United States for allegedly helping to censor conservative opinions about COVID-19 vaccines and government elections.'

https://www.nature.com/articles/d41586-023-02195-3

cyrilpedia, 10 months ago to random

Quoi?

'We find that at least half of TFs also bind RNA, doing so through a previously unrecognized domain with sequence and functional features analogous to the arginine-rich motif of the HIV transcriptional activator Tat.'

https://www.cell.com/molecular-cell/fulltext/S1097-2765(23)00434-3?rss=yes&utm_source=dlvr.it&utm_medium=mastodon

gpollara, 10 months ago (edited 10 months ago) to academicchatter

So many good points in this piece by
@PhilippBayer

My highlight in this screenshot (#science delivery & success is a TEAM effort!), but if you're vaguely involved in #academia +/- #bioinformatics, do have a read and think how it all may apply to you. #academicchatter @academicchatter
https://genomic.social/@PhilippBayer/110644840476993836

schoppik, 10 months ago to random

@analog_ashley there’s @mekkaokereke and @KimCrayton1 and @BlackAzizAnansi all worth listening to.

NicoleCRust, 10 months ago to science

Metaphors in science - know any?

I’m fascinated by the role that metaphors play in scientific discovery. Like Darwin’s “tree” of life. When we shift how we think about what we’re working on, sometimes it inspires us to see it in a whole new way that clicks.

Know any good accounts of metaphors in science - others or your own?

#science #metaphor

cyrilpedia, 10 months ago to random

I love Current Biology - probably my favorite journal ever since I haunted the university library waiting for each new issue to read Sidney Brenner's Loose Ends. But maybe "Free Vaginas" is not the best layout option for their webpage.

stefan, 10 months ago to til

Apparently the phrase "you're toast" originates from the 1984 Ghostbusters movie.

https://www.giantfreakinrobot.com/ent/bill-murray-ghostbusters-toast.html

#til #language #toast #history #linguistics

cyrilpedia, 10 months ago to random

'If height is an indicator of social conditions in childhood, including nutrition, is it possible that social conditions for children in the UK are worse than in many other countries and deteriorated during the decade after 2010?

It is highly plausible.'

https://www.theguardian.com/commentisfree/2023/jun/25/britains-shorter-children-reveal-a-grim-story-about-austerity-but-its-scars-run-far-deeper

cyrilpedia, 11 months ago to random Japanese

No. No no no.

No.

cyrilpedia, 11 months ago to random

'The results highlight how widely and unpredictably disease severity and contagiousness vary between people. “And it’s that variability among humans that has made this virus so difficult to control,” says infectious-disease doctor Monica Gandhi at the University of California, San Francisco, who was not involved in the work. The study, published on 9 June in Lancet Microbe, also suggests that human physiology, not the virus, is to blame for some of the inconsistency of COVID-19'

https://www.nature.com/articles/d41586-023-01961-7

cyrilpedia, 11 months ago to random

'As science becomes increasingly accessible to the general public, racist agendas can now more easily use science to disinform. All scientists must pursue and accomplish anti-racism efforts to achieve change at the system level. Juneteenth can remind us of what we still need to change, but doing so requires action from funding bodies, institutions, and the wider community.'

https://www.cell.com/cell/fulltext/S0092-8674(23)00536-6

cyrilpedia, 11 months ago to random

My Clinical Pipeline column for Nature Medicine this week examines the state of Sarepta's new gene therapy for Duchenne muscular dystrophy application at the FDA. Whatever its final efficacy turns out to be, the general strategy behind the therapy, an engineered micro-dystrophin is very clever.

It was inspired by the case of a 61 year old patient who had a deletion of almost half of his dystrophin gene and was still alive and walking. Here's that ref, from 1990:
https://www.nature.com/articles/343180a0

And here's my column:

https://www.nature.com/articles/d41591-023-00052-4

cyrilpedia, 11 months ago to random

“There was an exchange on Twitter a while back where someone said, ‘What is artificial intelligence?’ And someone else said, ‘A poor choice of words in 1954’,” he says. “And, you know, they’re right. I think that if we had chosen a different phrase for it, back in the ’50s, we might have avoided a lot of the confusion that we’re having now.”

So if he had to invent a term, what would it be? His answer is instant: applied statistics.'

https://www.ft.com/content/c1f6d948-3dde-405f-924c-09cc0dcf8c84

cyrilpedia, 11 months ago to random

Good for them:

"Thousands of early-career researchers at the US National Institutes of Health (NIH) have kickstarted the process to form a union. They are calling on the NIH — the world’s largest biomedical funder — to raise pay and improve benefits, as well as to bolster its policies and procedures against harassment and excessive workloads."

https://www.nature.com/articles/d41586-023-01845-w

cyrilpedia, 1 year ago to random

Now that I've read the credits, I want to go back and pay more attention to Mr Lawrence's performance.

cyrilpedia, 1 year ago to random

'These results indicate that NRF2 regulates cardiac metabolic reprogramming by stimulating the diversion of glucose into the PPP, thereby providing cardiac protection during stress by generating NADPH and providing nucleotides to prevent stress-induced DNA damage.'
#Preprint

https://www.biorxiv.org/content/10.1101/2023.05.12.540342v1?med=mas

cyrilpedia, 1 year ago to random

CART cells beyond cancer - my latest Clinical Pipeline column for Nature Medicine is out. CAR T cell technology in humans was first tried for HIV in the 90s. Now veteran HIV researchers are giving them another shot.

#immunotherapy #publichealth #hiv #Immunology #cartcells
#ScienceCommunication #SciComm #InfectiousDisease

https://www.nature.com/articles/d41591-023-00042-6

NicoleCRust, 1 year ago to random

On the art of nonfiction, David Shenk.

This article and its 3 challenges to writing nonfiction resonates with me. It also highlights the difference between scientific practice versus science writing of other types (with a surprising insight for science practice).

The second challenge is the one that both scientists and science writers do a lot of: figuring out how to navigate complex information. It's the core of the job, whether you are practicing science or writing about it.

The first challenge is the one that most scientists don't do much of: storytelling science. For the scientists that want to do it, that's great. But it's also really hard. While tremendously valuable to the whole, I'm not sure it turns individuals into better scientists; it's a different (valuable!) thing. Of the 3 challenges, this one differentiates science writers vs scientists. (The analog in science would be the experiments and such).

The third challenge is the one that is less obvious: Stepping back from the trees to view the forest from 10,000 feet to get a fresh perspective. I agree with Shenk that most scientists don't do it. It's one I'd like to see more scientists engage in; I suspect it would lead to better science.

#writing #nonfiction

https://www.theatlantic.com/national/archive/2009/11/on-the-art-of-non-fiction/30107/

cyrilpedia, 1 year ago to random

'The EU is ready to agree that immediate open access to papers reporting publicly funded research should become the norm, without authors having to pay fees, and that the bloc should support non-profit scholarly publishing models.'

https://www.researchprofessionalnews.com/rr-news-europe-infrastructure-2023-5-eu-ready-to-back-immediate-open-access-without-author-fees/

npariente, 1 year ago to random

RT @matthewcobb
70 years ago, 3 papers appeared in @Nature under the title ‘Molecular structure of nucleic acids’. In an article in Nature today (link at end) @nccomfort and I shed new light on ‘what Watson and Crick really took from Rosalind Franklin’. This thread summarises our findings. 1/23

1953 Nature article by Wilkins et al.
1953 Nature article by Franklin and Gosling – page 1
1953 Nature article by Franklin and Gosling – page 2

wandrew, 1 year ago to random

hello new users, welcome to the social media equivalent of greendale community college